RENEWED Pro

Peptide Science & Clinical Evidence

Peer-reviewed science, not guesswork.

Peptides are short chains of amino acids that act as cellular messengers within the body, supporting targeted biological pathways. RENEWED Pro arms reps with the full published library of AI-discovered, clinically investigated bioactive peptides — from cutaneous collagen signaling to muscle remodeling and inflammaging.

Bioactive peptide serum in luxury glass bottle with gold pipette

What makes bioactive peptides different?

Instead of just flooding the body with generic protein building blocks, Bioactive Precision Peptides™ target the underlying cell-to-cell communication networks.

SIGNAL

Peptides act as cellular messengers that bind specific receptors, telling fibroblasts to support collagen and elastin.

PRESERVE

Bioactive sequences balance tissue breakdown enzymes while promoting healthy structural resilience.

AI PRECISION

Computational proteome mining identifies the exact bioactive fragments in minutes that nature evolved over millennia.

★ Key Clinical StudyInt. Journal of Cosmetic Science · PMID: 32453870

The anti-ageing effects of a natural peptide discovered by artificial intelligence

Randomized 28-day proof-of-concept + human skin explants: Evaluates peptide pep_RTE62G (PeptiYouth™) unlocked from Pisum sativum via deep learning. Proved significant stimulation of extracellular matrix (ECM) neosynthesis of collagen and elastin, enhanced keratinocyte migration in wound-healing assays, and measurable anti-wrinkle efficacy.

K. Kennedy, R. Cal, R. Casey, C. Lopez, A. Adelfio, B. Molloy, A.M. Wall, T.A. Holton, N. Khaldi

Scientific Foundation

Backed by rigorous, peer-reviewed literature.

15+

Peer-Reviewed Studies

Published in leading journals

56

Patents Issued

Protecting bioactive sequences

860+

Years Combined Research

In silico & in vivo science

28-day

Clinical Proof of Concept

Cutaneous ECM activity

The Published Literature

◆

Peer-reviewed publications from Nuritas research.

Every peptide technology RENEWED reps present is rooted in peer-reviewed clinical trials, in vitro validation, and AI discovery papers published in leading international journals.

Int'l J. Cosmetic Sci.
International Journal of Cosmetic Science·2020, Vol. 42 (PMID: 32453870)PeptiYouth™

The anti-ageing effects of a natural peptide discovered by Artificial Intelligence

Authors: Kathy Kennedy, Roi Cal, Rory Casey, Cyril Lopez, Alessandro Adelfio, Brendan Molloy, Audrey M Wall, Thérèse A Holton, Nora Khaldi

Key Finding: Randomized proof-of-concept 28-day clinical study + human skin explants demonstrating that AI-discovered peptide pep_RTE62G significantly stimulates ECM neosynthesis of collagen and elastin, keratinocyte migration, and anti-wrinkle cellular vitality.

J. Derm. & Cosm.
Journal of Dermatology and Cosmetology·2020, Vol. 5PeptiYouth™

pep_35E7UW, a natural peptide with cutaneous anti-ageing effects discovered within the Oryza Sativa proteome through machine learning

Authors: Kathy Kennedy, Roi Cal, Rory Casey, Therese Holton, Alessandro Adelfio, Audrey Wall, Nora Khaldi

Key Finding: Machine-learning identified rice-derived peptide evaluated in human dermal fibroblasts, keratinocytes, wound-healing models and human skin explants for anti-aging signaling.

BMJ Nutrition
BMJ Nutrition, Prevention & Health·2025, March 2025PeptiStrong®

Randomised, double-blind, placebo-controlled study to evaluate the effect on human strength and endurance after resistance training and supplementation of Vicia faba protein hydrolysate compared with placebo

Authors: Niamh Máire Mohan, Nora Khaldi, Brian Keogh, Andy Franklyn-Miller

Key Finding: Human double-blind RCT evaluating strength, muscular endurance, and functional recovery after resistance training with bioactive peptide hydrolysate supplementation.

Nutrients
Nutrients·2023, Vol. 15PeptiStrong®

Improved Strength Recovery and Reduced Fatigue with Suppressed Plasma Myostatin Following Supplementation of a Vicia faba Hydrolysate, in a Healthy Male Population

Authors: Alish Kerr, Luke Hart, Heidi Davis, Audrey Wall, Seán Lacey, Andrew Franklyn-Miller, Nora Khaldi, Brian Keogh

Key Finding: Significant improvement in post-exercise strength recovery, lower subjective fatigue, and suppressed plasma myostatin in healthy human subjects.

J. of Nutrition
The Journal of Nutrition·2023, Vol. 153PeptiStrong®

Vicia faba Peptide Network Supplementation Does Not Differ From Milk Protein in Modulating Changes in Muscle Size During Short-Term Immobilization and Subsequent Remobilization, but Increases Muscle Protein Synthesis Rates During Remobilization in Healthy Young Men

Authors: Michelle E.G. Weijzen, Jorn Trommelen, Imre W.K. Kouw, Andrew M. Holwerda, Janneau van Kranenburg, Henrike M. Hamer, Annemarie P. Gijsen, Joy P.B. Goessens, Alessandro Adelfio, Nora Khaldi, Luc J.C. van Loon

Key Finding: Demonstrated that plant-derived bioactive peptide network increases muscle protein synthesis rates during remobilization, matching and in specific metrics surpassing dairy benchmark.

Current Res. Food
Current Research in Food Science·2021, Vol. 4PeptiStrong®

Characterising the efficacy and bioavailability of bioactive peptides identified for attenuating muscle atrophy within a Vicia faba-derived functional ingredient

Authors: Alberto R. Corrochano, Roi Cal, Kathy Kennedy, Audrey Wall, Niall Murphy, Sanja Trajkovic, Sean O’Callaghan, Alessandro Adelfio, Nora Khaldi

Key Finding: Characterized high bioavailability, intestinal absorption pathways, and anti-atrophy cellular signaling of identified precision peptide sequences.

Nutrients
Nutrients·2020, Vol. 12PeptiStrong®

Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy

Authors: Roi Cal, Heidi Davis, Alish Kerr, Audrey Wall, Brendan Molloy, Sweeny Chauhan, Sanja Trajkovic, Ian Holyer, Alessandro Adelfio, Nora Khaldi

Key Finding: Preclinical in vitro and in vivo validation demonstrating protection against muscle protein degradation and support for anabolic signaling pathways.

Frontiers Genetics
Frontiers in Genetics·2021, Nov 2021AI Platform

Artificial Intelligence in Functional Food Ingredient Discovery and Characterisation: A Focus on Bioactive Plant and Food Peptides

Authors: Aoife Doherty, Audrey Wall, Nora Khaldi, Martin Kussmann

Key Finding: Details how deep learning and computational proteome mining unlock targeted peptide sequences far faster than traditional trial-and-error discovery.

Nutrients
Nutrients·2021, Vol. 13AI Platform

An Artificial-Intelligence-Discovered Functional Ingredient, NRT_N0G5IJ, Derived from Pisum sativum, Decreases HbA1c in a Prediabetic Population

Authors: Sweeny Chauhan, Alish Kerr, Brian Keogh, Stephanie Nolan, Rory Casey, Alessandro Adelfio, Niall Murphy, Aoife Doherty, Heidi Davis, Audrey M. Wall, Nora Khaldi

Key Finding: Human clinical study showing an AI-discovered pea peptide ingredient significantly decreased HbA1c in prediabetic subjects, validating translation from in silico prediction to in vivo efficacy.

J. Bio- medicines
Journal of Biomedicines·2021, Vol. 9AI Platform

Discovery through Machine Learning and Preclinical Validation of Novel Anti-Diabetic Peptides

Authors: Rory Casey, Alessandro Adelfio, Martin Connolly, Audrey Wall, Ian Holyer, Nora Khaldi

Key Finding: Validation of machine-learning models predicting GLP-1 and glucose-modulating bioactivities from natural plant peptides.

Food & Function
Food and Function·2019, Vol. 10AI Platform

Artificial intelligence identified peptides modulate inflammation in healthy adults

Authors: Dietrich Rein, Philipp Ternes, Rodion Demin, Jürgen Gierke, Thrandur Helgason, Christiane Schön

Key Finding: Randomized, double-blind, crossover clinical trial showing AI-identified peptides modulated inflammatory biomarkers in healthy human subjects.

Foods
Foods·2020, Vol. 9AI Platform

An artificial intelligence characterised functional ingredient, derived from rice, inhibits TNF-α and significantly improves physical strength in an inflammaging population

Authors: Kathy Kennedy, Brian Keogh, Cyril Lopez, Alessandro Adelfio, Brendan Molloy, Alish Kerr, Audrey M. Wall, Gaël Jalowicki, Thérèse A. Holton, Nora Khaldi

Key Finding: Human clinical trial demonstrating AI-characterised rice peptide ingredient inhibits TNF-α and supports muscular and physical strength in an inflammaging demographic.

Frontiers Microbiol.
Frontiers in Microbiology·2019, Vol. 10PeptiSave™

Unlocking a Potent Antimicrobial Peptide from a Common Pea

Authors: Niamh M. Mohan, Amine Zorgani, Gael Jalowicki, Alish Kerr, Nora Khaldi, Marta Martins

Key Finding: Identified and characterized a potent natural antimicrobial peptide from pea protein with targeted activity against pathogenic microorganisms.

Food Sci. & Nutr.
Food Science & Nutrition·2021, Vol. 9PeptiSave™

Preservatives from food – For food: Pea protein hydrolysate as a novel bio-preservative against Escherichia coli O157:H7 on a lettuce leaf

Authors: Niamh M. Mohan, Amine Zorgani, Leah Earley, Sweeny Chauhan, Sanja Trajkovic, John Savage, Alessandro Adelfio, Nora Khaldi, Marta Martins

Key Finding: Demonstrated natural antimicrobial efficacy of plant-derived peptide hydrolysate as a safe bioactive alternative to synthetic chemical preservatives.

Current Res. Food
Current Research in Food Science·2020, Vol. 3Infant Formula

Human milk and infant formulae: peptide differences and the opportunity to address the functional gap

Authors: Cyril Lopez, Alessandro Adelfio, Audrey M. Wall, Brendan Molloy, Thérèse A. Holton, Nora Khaldi

Key Finding: High-resolution mass-spectrometry mapping of natural peptide profiles, detailing structural differences and physiological bioactivity.

Rep Compliance Context: These peer-reviewed publications evaluate identified bioactive peptide sequences, mechanisms of action, and functional ingredients across preclinical and human clinical models conducted by Nuritas and collaborating academic institutions. Reps must clearly distinguish between published ingredient-level studies and finished-product clinical trials when speaking to dermatologists and plastic surgeons.

Research & Claims Integrity

The honest line reps never cross.

Ingredient-level research

Published studies and 'clinically studied' claims apply to identified peptide sequences, mechanisms, and hydrolysates, not the finished retail packaging.

Structure / Function language

Use compliant phrasing: helps support, promotes the appearance of, maintains healthy skin barrier, and assists cellular communication over time.

Individual patient results

Benefits are not guaranteed cures or drug interventions. Rep sheets must state clearly that individual results may vary.

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